FzM1
In vial of 0.5 g net
TargetMol Chemicals Inc.
Product Overview
Product / Grade Name
FzM1
Maker Name
Product Description
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
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