Trimethylamine N-oxide dihydrate
In vial of 1 g. net
TargetMol Chemicals Inc.
Product Overview
Product / Grade Name
Trimethylamine N-oxide dihydrate
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Product Description
Trimethylamine N-oxide dihydrate (TMANO dihydrate) is a gut microbiota-dependent metabolite derived from dietary choline and other trimethylamine-containing nutrients. It induces inflammation by activating the ROS/NLRP3 inflammasome and promotes fibroblast differentiation and cardiac fibrosis via the TGF-β/Smad2 signaling pathway. TMANO dihydrate can be used to establish models of cardiac hypertrophy and cardiac fibrosis.
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